Biology 152 Lecture 1 Section 1 Lessons Help Instructor Resources About

Cell Biology > Thermodynamics > Topic 3: ATP

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How does the cell make thermodynamically unfavorable reactions go? One solution is to team up or "couple" an endergonic reaction with an exergonic one: for example, the hydrolysis of ATP to ADP + Pi + energy.

Certain enzymes make this coupling possible. These enzymes catalyze a reaction by taking energy from ATP and transferring it to other reactants. Some enzymes transfer a high energy phosphate from ATP to another reactant. We call the resulting molecule a phosphorylated intermediate.


What You'll Learn in this Topic

  • The steps involved in coupling ATP hydrolysis to a sample endergonic reaction: the glutamine synthetase reaction.
  • How one type of phosphorylated intermediate is formed.

Your task is to solve a mystery: Where did ATP's energy go in the glutamine synthetase reaction?

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